Optical Theory Group

Abstract : Digital assays represent a shift from traditional diagnostics and enable the precise detection of low-abundance analytes, critical for early disease diagnosis and personalized medicine, through discrete counting of biomolecular reporters. Within this paradigm, we present a particle counting algorithm for nanoparticle based imaging assays, formulated as a multiple-hypothesis statistical test under an explicit image-formation model and evaluated using a penalized likelihood rule. In contrast to thresholding or machine learning methods, this approach requires no training data or empirical parameter tuning, and its outputs remain interpretable through direct links to imaging physics and statistical decision theory. Through numerical simulations we demonstrate robust count accuracy across weak signals, variable backgrounds, magnification changes and moderate PSF mismatch. Particle resolvability tests further reveal characteristic error modes, including under-counting at very small separations and localized over-counting near the resolution limit. Practically, we also confirm the algorithm’s utility, through application to experimental dark-field images comprising a nanoparticle-based assay for detection of DNA biomarkers derived from SARS-CoV-2. Statistically significant differences in particle count distributions are observed between control and positive samples. Full count statistics obtained further exhibit consistent over-dispersion, and provide insight into non-specific and target-induced particle aggregation. These results establish our method as a reliable framework for nanoparticle-based detection assays in digital molecular diagnostics.

Abstract : Spectral degeneracies, including diabolic (DP) and exceptional (EP) points, exhibit unique sensitivity to external perturbations, enabling powerful control and engineering of wave phenomena. We present a residue-based perturbation theory that quantifies complex resonance splitting of DP and EP type spectral degeneracies using generalized Wigner–Smith operators. We validate our theory using both analytic Hamiltonian models and numerical electromagnetic simulations, demonstrating excellent agreement across a range of cases. Our approach accurately predicts degenerate resonance splitting using only scattering data, offering a powerful framework for precision tuning, inverse design, and practical exploitation of non-Hermitian phenomena.

Abstract : Exceptional points (EPs) in non-Hermitian photonic systems have attracted considerable research interest due to their singular eigenvalue topology and associated anomalous physical phenomena. These properties enable diverse applications ranging from enhanced quantum metrology to chiral light-matter interactions. Practical implementation of high order EPs in optical platforms however remains fundamentally challenging, requiring precise multi-parameter control that often exceeds conventional design capabilities. This work presents a novel framework for engineering high order EPs through transformation optics (TO) principles, establishing a direct correspondence between mathematical singularities and physically controllable parameters. Our TO-based paradigm addresses critical limitations in conventional Hamiltonian approaches, where abstract parameter spaces lack explicit connections to experimentally accessible degrees of freedom, while simultaneously providing full-field mode solutions. In contrast to prevailing parity-time-symmetric architectures, our methodology eliminates symmetry constraints in EP design, significantly expanding the possibilities in non-Hermitian photonic engineering. The proposed technique enables unprecedented control over EP formation and evolution in nanophotonic systems, offering new pathways for developing topological optical devices with enhanced functionality and robustness.